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A Minor Drug Interaction exists between prednisone and Xanax. View detailed information regarding this drug interaction. The lists of medications in this section are not meant to be all-inclusive or comprehensive, but rather address the most common concerns. For any medication, the AME should ascertain for what condition the medication is being used, how long, frequency, and any side effects of the medication. The safety impact of the underlying condition should also be considered. If there are any questions, please call the Regional Flight Surgeon's (RFS) office or the Aerospace Medicine Certification Division (AMCD). AMEs should not issue airmen medical certificates to applicants who are using these classes of medications or medications. Airmen should not fly while using any of the medications in the Do Not Issue section above or while using any of the medications or classes/groups of medications listed below without an acceptable wait time after the last dose. All of these medications may cause sedation (drowsiness) and impair cognitive function, seriously degrading pilot performance. This impairment can occur even when the individual feels alert and is apparently functioning normally - in other words, the airman can be "unaware of impair." For aviation safety, airmen should not fly following the last dose of any of the medications below until a period of time has elapsed equal to: Label warnings. Airmen should not fly while using any medication, prescription or OTC, that carries a label precaution or warning that it may cause drowsiness or advises the user "be careful when driving a motor vehicle or operating machinery." This applies even if label states "until you know how the medication affects you" and even if the airman has used the medication before with no apparent adverse effect. Alcohol is one of those substances that seems to clash with everything and anything. 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