They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Benlysta and plaquenil Chloroquine lysosome inhibitor Does anyone know if Plaquenil lowers your immune system? My daughter started school in August and since then I have had one illness after another. I don't know if it's the disease itself or the medication. Or maybe it's just normal when your kid starts school. Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD. It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Your browser does not support the NLM PubReader view. The body weight, serum biochemical parameters, immune and inflammatory. including reducing damage, lowering the risk of developing nephritis and improving the. of numerous pro-inflammatory cytokines during the immune response 1. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Does hydroxychloroquine lower your immune system Symptoms of Immune System Problems - WebMD, Hydroxychloroquine Side-effects, uses, time to work Chloroquine phosphate tablets side effects Higher doses of medications that weaken your immune system are more likely to increase your risk of getting a fungal infection. 5,11,13,14 Click on the sections below to see lists of corticosteroids and TNF inhibitors that can increase the chances of getting a fungal infection. Medications that Weaken Your Immune System and Fungal.. Immunosuppressive effects of hydroxychloroquine and. - NCBI. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Almost all autoimmune diseases require the immune system be suppressed to some degree. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used.