Chloroquine use in sle

Discussion in 'Plaquenil Generic' started by Rabbit, 18-Mar-2020.

  1. palmoman Well-Known Member

    Chloroquine use in sle


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Hydroxychloroquine HCQ, is a 4-aminoquinoline drug used widely in autoimmune disease, but has also been employed for the treatment of malaria,1 where it is reported as being half as toxic as the closely-related chloroquine CQ yet equally active against Plasmodium falciparum.2 In UK travel medicine, three drug regimens atovaquone–proguanil, mefloquine or doxycycline are currently recommended for use in sub-Saharan Africa and other areas with high transmission rates of CQ-resistant P. Lupus Systemic Lupus Erythematosus or SLE Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine use in sle

    Chloroquine treatment influences proinflammatory cytokine., Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria

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  6. Chloroquine and hydroxychloroquine are drugs derived from the quinoline molecule. Both are used as antimalarial blood schizonticides, and hydroxychloroquine is also frequently used as an antirheumatic. Their mechanism of action is not entirely understood.

    • Chloroquine and hydroxychloroquine – Knowledge for medical students and..
    • Hydroxychloroquine Uses, Dosage & Side Effects -.
    • Chloroquine - Wikipedia.

    The aminoquinolones chloroquine and hydroxychloroquine have been widely used in the treatment of SLE. These drugs can cause a reversible, visually insignificant keratopathy cornea verticillata and, more importantly, an irreversible sight-threatening maculopathy. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. 1 It is taken by mouth. Chloroquine is a medication first developed as an anti-malarial that has been used for many years to help treat lupus systemic lupus erythematosus, or SLE and rheumatoid arthritis. If a patient responds to treatment with an anti-malarial, in general it will continue to be used indefinitely.

     
  7. 106_8 Well-Known Member

    Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Plaquenil - FDA prescribing information, side effects and uses Hydroxychloroquine-related retinal toxicity Rheumatology. Mechanisms of action of hydroxychloroquine and chloroquine.
     
  8. SeoFDI New Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Plaquenil Hydroxychloroquine myRAteam Rx Side Effects New Plaquenil Guidelines and More - American.
     
  9. Gruber New Member

    Proguanil and Chloroquine - NPA NPA It is preferable to avoid crushing tablets; however, chloroquine, proguanil, mefloquine and atovaquone/proguanil tablets may be crushed and mixed with jam, honey, pasteurised yoghurt or similar for ease of administration to young children. Tablets may be cut using tablet cutters where necessary.

    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs