There’s no cure for arthritis, which is unfortunate, but feeling better is definitely possible. The progression of RA may be diminished in severity and duration by the combination of medicines and therapy that work best as determined by you and your physician. Plaquenil retinal toxicity night vision Use of plaquenil for osteoarthritis The distinction between using methotrexate to treat cancer and to treat rheumatoid arthritis is important. Technically speaking, methotrexate is a “cancer drug” — and it’s used to treat different kinds of cancer, including breast cancer. That’s because methotrexate attacks fast-dividing cells, which include cancer cells. Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate. Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate. Myelosuppression lowering of blood counts is also rare at the low doses of methotrexate utilized for rheumatoid arthritis. Patients at particular risk include those with renal insufficiency from other causes or use of trimethoprim Bactrim®, Septra® which increases levels of methotrexate. Being able to stop joint damage can lessen pain and mean a better quality of life. You can also put off joint damage, and in some cases, you can do more than just slow it down. Methotrexate and hydroxychloroquine for rheumatoid arthritis Leflunomide, Sulfasalazine and Hydroxychloroquine for., Combination therapy with methotrexate and hydroxychloroquine for. Plaquenil-for-malaria-treatment-to-managing-lupus-raWhat does hydroxychloroquine treatSide effects from stopping plaquenilPlaquenil dosage for discoid lupusI take 2 hydroxychloroquine Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Compare Plaquenil vs Methotrexate -. Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center. Combination therapy with methotrexate and hydroxychloroquine.. Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis. One of the most popular and also most effective of these is a folate analog called methotrexate MTX. It’s a treatment option with one of the longest and most well-established safety profiles of any rheumatoid arthritis drug on the market.