Low-dose hydroxychloroquine in treatment of porphyria

Discussion in 'Online Canadian Pharmacy' started by Tony111, 20-Mar-2020.

  1. Dmn XenForo Moderator

    Low-dose hydroxychloroquine in treatment of porphyria


    These disorders are usually inherited, meaning they are caused by abnormalities in genes passed from parents to children. When a person has a porphyria, cells fail to change body chemicals called porphyrins and porphyrin precursors into heme, the substance that gives blood its red color.

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    There are two current treatments for PCT. The first and more common treatment is repeated phlebotomies removing blood, but that also includes the potential disadvantages of discomfort, inconvenience and expense. The second options is a low-dose treatment with medications that are normally used to treat malaria-- hydroxychloroquine or chloroquine. Porphyria cutanea tarda PCT is an iron-related disorder that responds to treatment by phlebotomy or low-dose hydroxychloroquine, but comparative data on these treatments are limited. The hypothesis is that hydroxychloroquine is noninferior to phlebotomy in terms of time to remission. Porphyria cutanea tarda PCT is a term encompassing a group of acquired and familial disorders in which activity of the heme synthetic enzyme uroporphyrinogen decarboxylase UROD is deficient. Approximately 80% of all cases of porphyria cutanea tarda are acquired; 20% are familial, although the ratio may vary among different geographic regi.

    Bone marrow is the soft, spongelike tissue inside the bones; it makes stem cells that develop into one of the three types of blood cells—red blood cells, white blood cells, and platelets. The body makes heme mainly in the bone marrow and liver.

    Low-dose hydroxychloroquine in treatment of porphyria

    Hydroxychloroquine Professional Patient Advice -, Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda.

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  3. There were no significant side effects of either treatment. CONCLUSIONS Hydroxychloroquine, 100 mg twice weekly, is as effective and safe as phlebotomy in patients with PCT, although noninferiority was not established. Given these results, higher-dose regimens of hydroxychloroquine, which have more side effects, do not seem justified.

    • Low-dose hydroxychloroquine is as effective as phlebotomy in treatment..
    • Porphyria Cutanea Tarda Treatment & Management Medical..
    • Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in..

    High-dose hydroxychloroquine treatment of porphyria cutanea tarda Carsten Sand Petersen, MD, and Kristian Thomsen, MD Copenhagen, Denmark Background High-dose hydroxychloroquine is rarely used in the treatment of porphyria cutanea tarda PCT. Dec 20, 2019 Porphyria cutanea tarda PCT is a term encompassing a group of acquired and familial disorders in which activity of the heme synthetic enzyme uroporphyrinogen decarboxylase UROD is deficient. Approximately 80% of all cases of porphyria cutanea tarda are acquired; 20% are familial, although the ratio may vary among different geographic regi. Porphyria cutanea tarda PCT is an iron-related disorder that results from reduced activity of hepatic uroporphyrinogen decarboxylase. Treatment options include phlebotomy or low doses of hydroxychloroquine. Phlebotomy is expensive, inconvenient, and can increase risk for anemia or syncope.

     
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    Download PDF Many systemic medications may cause retinal toxicity. The Royal College of Ophthalmologists recommendations on. - Eye Recommendations on Screening for Chloroquine and. Plaquenil Side Effects on Your Eyes and Vision
     
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    Aralen Chloroquine Uses, Dosage, Side Effects. Before using chloroquine for prophylaxis, it should be ascertained whether chloroquine is appropriate for use in the region to be visited by the traveler. Chloroquine should not be used for treatment of P. falciparum infections acquired in areas of chloroquine resistance or malaria occurring in patients where chloroquine prophylaxis has failed.

    CDC - Malaria - Malaria Worldwide - How Can Malaria Cases.