Synthesis of chloroquine from 4 7 dichloroquinoline

Discussion in 'Hydroxychloroquine Plaquenil' started by naleks, 09-Mar-2020.

  1. Fregl User

    Synthesis of chloroquine from 4 7 dichloroquinoline


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    The bulk common intermediate 3 was prepared using a modification of De's method in which 4,7-dichloroquinoline was allowed to react with neat diaminopropane to afford 3. 17 In initial studies we consistently achieved lower yields then reported due to the formation of a coarse particulate precipitate during the wash step of the work-up. Representative procedure for the synthesis of compounds 11–15. To a solution of 6 0.070 g, 0.22 mmol in 5 mL of glacial acetic acid, NaBH 4 0.293 g, 7.7 mmol was added at 0 ° C and the reaction temperature was increased to 60 ° C. After 48 hours, the reaction mixture was cooled, basified with saturated NaOH. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

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    Synthesis of chloroquine from 4 7 dichloroquinoline

    Chloroquine - an overview ScienceDirect Topics, Synthesis and antimalarial activity of new chloroquine.

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  6. SYNTHESIS AND ANTIMALARIAL EVALUATION OF A. of dual-drug, artesunate, chloroquine CQ, 4,7-dichloroquinoline DQ against CQ-sensitive D6 and -resistant. of a linker to 4,7-dichloroquinoline and subsequent coupling with artesunate to form the dual drug. The reactions were monitored by TLC and the compounds purified by

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    It's a pretty untypical approach to chloroquine and you didn't tell how you would synthesize 7-chloro-3-aminoquinoline and the secondary chloride. There is a good chance that the planned reaction will furnish a quarternary ammonium salt as a side product The reaction will not necessary stop at this point. This article is cited by 7 publications. Ali Daneshfar and Saber Vafafard. Solubility of Chloroquine Diphosphate and 4,7-Dichloroquinoline in Water, Ethanol, Tetrahydrofuran, Acetonitrile, and Acetone from 298.2 to 333.2 K. Journal of Chemical & Engineering Data 2009, 54 8, 2170-2173. A New Synthesis of Chloroquine

     
  7. Josie Moderator

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine - Side Effects, Dosage, Interactions. Plaquenil and Vitamin b12 drug interactions - eHealthMe Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.
     
  8. alex757 Moderator

    Hydroxychloroquine MedlinePlus Drug Information Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments.

    Plaquenil Hydroxychloroquine - Side Effects, Dosage.
     
  9. blazer-05 User

    Hydroxychloroquine Plaquenil Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness.

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