Kinetics of chloroquine

Discussion in 'Hydroxychloroquine Plaquenil' started by SneganKA, 19-Mar-2020.

  1. Pantalone New Member

    Kinetics of chloroquine


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

    Rheumatoid arthritis guidelines hydroxychloroquine monotherapy Chloroquine hydrochloride

    This paper presents the current state of knowledge on chloroquine disposition, with special emphasis on stereoselectivity and microsomal metabolism. In addition, the impact of the patient’s physiopathological status and ethnic origin on chloroquine pharmacokinetics is discussed. In humans, chloroquine concentrations decline multiexponentially. The drug is extensively distributed, with a. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. In order to determine the pharmacokinetic disposition of chloroquine CQ and its active metabolite, desethylchloroquine DECQ, when administered as intermittent presumptive treatment in pregnancy IPTp for malaria, 30 Papua New Guinean women in the.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Kinetics of chloroquine

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures., Chloroquine C18H26ClN3 - PubChem

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  3. The real-time experimental data obtained by capacitive sensing also revealed two distinctive kinetics stages during binding of dsDNA with chloroquine, while only one stage exists during reaction of single-strand DNA ssDNA with chloroquine. The kinetic parameters were obtained by fitting the real-time experimental data using a two stage.

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    The kinetics of uptake of chloroquine into isolated rat hepatocytes were studied to further investigate whether they are consistent with accumulation of chloroquine at therapeutic concentrations that is predominantly due to lysosomal trapping. Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. The distribution of chloroquine was studied in the tissues and blood of rat. 2. 2. The time to peak concentration and the maximum concentration varied in various tissues and were higher than for plasma and red blood cells.

     
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    PLAQUENIL® PLAQUENIL is indicated for the treatment of acute attacks and suppression of malaria. Warning In recent years, it has been found that certain strains of P. falciparum have become resistant to 4-aminoquinoline compounds including hydroxychloroquine as shown by the fact

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