Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. The mechanism of this toxicity is not clearly understood, though it is believed that the drug molecule binds to melanin in the retinal pigment epithelium (RPE). How about taking half of plaquenil Pics of corneal chloroquine toxicity Chloroquine hydrochloride injection The deneric plaquenil is not as good as non generic Bernstein HN. Ocular safety of hydroxychloroquine sulfate Plaquenil. South Med J. 1992 Mar; 85 3274–279. Easterbrook M. The ocular safety of hydroxychloroquine. Semin Arthritis Rheum. 1993 Oct; 23 2 Suppl 162–67. Mackenzie AH. Dose refinements in long-term therapy of rheumatoid arthritis with antimalarials. Hydroxychloroquine balancing the need to maintain therapeutic levels with ocular safety an update. Abdulaziz N1, Shah AR2, McCune WJ1. Author information 1Division of Rheumatology, Department of Internal Medicine. 2Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA. Apr 20, 2011 A 45-year-old black female presented with no ocular or visual complaints. Her ocular history was unremarkable. However, her medical history was significant for a recent diagnosis of lupus. Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil hydroxychloroquine, Sanofi-Aventis therapy. Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. This leads to disruption and damage to the photoreceptors and outer nuclear and plexiform layer, sparing the foveal center and resulting in the “bull’s eye” appearance in the late stage of the disease. Ocular safety of hydroxychloroquine Plaquenil Risk Calculators, Hydroxychloroquine balancing the need to maintain. Does prednisone and plaquenil work for ankylosing spondylitis Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Hydroxychloroquine Side Effects, Dosage, Uses, and More. New Plaquenil Guidelines. Hydroxychloroquine-related retinal toxicity Rheumatology.. Ocular safety of hydroxychloroquine. Ann Ophthalmol. 1991; 238292-6 ISSN 0003-4886 Bernstein HN. Analysis of all published cases and Food and Drug Administration reports of retinopathy induced by hydroxychloroquine did not show any evidence of permanent visual-field scotomas occurring when the daily dose did not exceed 6.5 mg/kg body. Jan 05, 2020 Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Ocular manifestations of hydroxychloroquine include corneal verticillata and retinal toxicity. Verticillata are cornea deposits of salts within the corneal epithelium. This condition does not cause symptoms and is reversible with cessation of the medication.