Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Artemisinin-based combination therapy chloroquine primaquine falciparum viva How does plaquenil affect vision Clinical practice guidelines recommend use of combination DMARDs such as hydroxychloroquine plus methotrexate for patients with a disease duration less than 6 months and moderate disease activity and poor prognostic features and is an option for high disease activity and poor prognostic features. Methotrexate is classified as a disease-modifying anti-rheumatic drug DMARD. The drug decreases pain and swelling associated with rheumatoid arthritis, slows progression of the disease, and helps prevent joint damage. When considering effectiveness and safety, is methotrexate injection better than oral methotrexate? Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Is plaquenil safer than methotrexate Methotrexate vs Plaquenil Comparison -, Is Injectable Methotrexate or Oral Methotrexate Better? Available doses of hydroxychloroquine Plaquenil vs Methotrexate. By Guest 1. meds. My RA has improved, I think, on the current regime of meds. Can you compare me Plaquenil and methotrexate, maybe methotrexate, would be better for me. Comparison of Plaquenil and methotrexate is difficult. Both drugs are very well tolerated and have different side effects, but if you have. Plaquenil vs Methotrexate Antineoplastics Cancer drugs.. Methotrexate vs plaquenil side effects long term and short term. DMARDs Disease-Modifying Antirheumatic Drugs – CreakyJoints. If a particular preparation is ineffective after a 4-week trial or is not tolerated, then another NSAID can be initiated. No one NSAID has been demonstrated to be better than another for the treatment of rheumatoid arthritis nor have the COX-2 agents been shown to be superior to traditional NSAIDS in terms of effectiveness. Usual Time to Effect Oct 09, 2015 Methotrexate or Plaquenil In Scleroderma Foundation Ok, here is a question that we all could probably use an answer to; Methotrexate or Plaquenil for CREST Scleroderma. Other than that I have had some GI issues when the Plaquenil was increased, but I seem to now be adjusting to it as well. Both have really helped as my inflammation markers are now back in the normal ranges in my blood work--they were 600 times normal before I began. I still have joint pain, but it is much less than before.