Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Synthesis of chloroquine ppt Does plaquenil help fatigue Oct chloroquine toxicity At first I started to have maybe half a day here and there without arthritis pain, then the fatique started to go away. I'd like to report that I never have symtoms or flares anymore, but I do, but I think the Plaquenil makes the difference between being a sick person pre-plaquenil and a normal person who occationally feels sick. Hydroxychloroquine should not be taken with other drugs that could cause heart arrhythmias irregular heart rate or rhythm. Taking hydroxychloroquine with these drugs could cause dangerous. Hi in case you see this - its been two years and I successfully cut my plaquenil and methotrexate in half with no return of symptoms. One week I forgot to take the meth and got a mild return of symptoms - scared the hell out of me but just resuming the same low dose squashed it. Now I'm trying to decide which is my next target. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Why plaquenil should not be cut in half Taking Plaquenil for Rheumatoid Arthritis, Hydroxychloroquine Side Effects, Dosage, Uses, and More Does hydroxychloroquine interact with levothryoxineChloroquine resistance prophylaxisHydroxychloroquine 200 mg for lupusPlaquenil and kidney disease I wouldn't break them in half, the medication that comes in a single pill without score mark, shouldn't be crushed or broken in half. You should check with your pharmacist though Reply Breaking pills in half hydrochloroquine/plaquinil? - LUPUS UK. Quitting methotrexate and plaquenil - Autoimmune Disorders - MedHelp. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. You should not use Plaquenil if you are allergic to hydroxychloroquine. Plaquenil should not be used for long-term treatment in children. To make sure Plaquenil is safe for you, tell your doctor if you have a history of vision changes or damage to your retina caused by an anti-malaria medication; My new rheumy, after running a trillion tests, has said that if it weren't for my previous rheumy's test results, he would say I did not have lupus. So, I asked about coming off of plaquenil. He said that I could stop plaquenil cold turkey. It slowly decreases effectiveness in the body.