So whenever something goes wrong inside, it eventually starts reflecting on the skin. One such sign is hyperpigmentation, a sign from your skin that all is not well within your body. How to treat plaquenil toxicity The trade name of chloroquine is Aug 14, 2013 Most commonly, its use can result in hyperpigmentation of the forehead, hard palate, forearms, and shins 2, 3; it can also cause pigmentation that appears on the cheek mucosa and nails 6, 11. The development of hydroxychloroquine-associated cutaneous dyschromia is not so rare and can present as black, blue-gray or blue discoloration in photodistributed areas or skin sites protected from the sun 6. Aug 18, 2011 Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few. It is mainly caused due to the overproduction of melanin, the pigment that gives skin its colour. Hyperpigmentation is a dermatological condition when the getting discoloured and darkened in places. Plaquenil cause hyperpigmentation Common and Rare Side Effects for Plaquenil Oral, Skin Discoloration and Plaquenil - Arthritis Information Can plaquenil be used for sgroens syndrDavis drug guide pdf hydroxychloroquinePlaquenil alternatives lupusSide effects aralen tablets Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. Hydroxychloroquine-Associated Hyperpigmentation. - PubMed Central PMC. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Drug-induced hyperpigmentation DermNet NZ. Health conditions that can cause hyperpigmentation Skin discolouration or hyperpigmentation is a sign of underlying health problems. Switch to हिंदी. PLAQUENIL has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with or without antidiabetic medications see DRUG INTERACTIONS and ADVERSE REACTIONS. Patients treated with PLAQUENIL should be warned about the risk of hypoglycemia and the associated clinical signs and. Treatment with HCQ was discontinued definitively because of skin pigmentation in 2 patients who reported a gradual incomplete fading of hyperpigmentation. Among patients who continued HCQ treatment n = 22, an improvement in pigmented lesions was reported in 6, despite the maintenance of a similar daily dose of HCQ.