Combination of plaquenil and methotrexate

Discussion in 'Canadian Pharcharmy' started by LC200, 23-Feb-2020.

  1. Annwin Moderator

    Combination of plaquenil and methotrexate


    Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems.

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    Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications Results of a two‐year, randomized, double‐blind, placebo‐controlled trial

    Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year.

    Combination of plaquenil and methotrexate

    The Combination of Leflunomide Arava and Methotrexate is., Effects of methotrexate and hydroxychloroquine combination.

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  7. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in.

    • Rheumatoid Arthritis Treatment Options Johns Hopkins..
    • Treatment of rheumatoid arthritis with methotrexate and..
    • Methotrexate Trexall Side Effects, Dosages, Treatment..

    This study evaluates the efficacy of the combination of methotrexate and hydroxychloroquine against leflunomide, a new DMARD as initial therapy in severe active rheumatoid arthritis. Hydroxychloroquine is known to increase the potency of methotrexate as well as increase its safety profile and reduce the dose. With Plaquenil, the possibility of permanent vision damage scares me. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. I've read elsewhere that Plaquenil is not as strong/effective in the treatment of early RA. With Methotrexate, the reports of nausea and possible liver damage are concerning. OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone.

     
  8. seohost XenForo Moderator

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  9. alexN User

    Daily Plaquenil Dosage - Crunching Numbers — Melton & Thomas describe the typical safe Plaquenil dosage this way The usual dosage is two 200mg tablets per day. This is generally a "safe" dose for patients having a lean body weight of at least 135 lbs. The generally-regarded safe dosage is 6.5mg/kg/qd, thus the 135 lb. safety threshold.

    The impact of different algorithms for ideal body weight.
     
  10. davenger User

    Chloroquine Phosphate Side Effects - GoodRx CHLOROQUINE is used to treat or prevent malaria infections. It is also used to treat amebiasis. The lowest GoodRx price for the most common version of chloroquine phosphate is around .38, 84% off the average retail price of 4.50.

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