Several years of treatment to suppress the immune system may be necessary to achieve these results. Those who don’t recover completely may need to continue on at least a low dose of medication to control the autoimmune attack of dermatomyositis throughout their lives. Anti malarial tablets chloroquine Hydroxychloroquine phosphate Best time of day to take plaquenil American academy of ophthalmology plaquenil guidelines Plaquenil hydroxychloroquine "I have dermatomyositis and have been taken Prednisone and Plaquenil. At first the combo was helping with the muscle pain and rash. At first the combo was helping with the muscle pain and rash. Generally, Plaquenil is a treatment option as monotherapy used alone for mild rheumatoid arthritis or as combination therapy with other DMARDs for moderate to severe disease. A Bit of History The origin of antimalarials dates back to the 1630s in Peru. The bark from the "fever tree' was found to contain the antimalarial compound, quinine. In dermatomyositis, an abnormal immune reaction appears to lead to obstructive inflammatory changes of blood vessels within muscle, connective tissues of the skin, and other tissues; patchy degeneration, wasting atrophy, and regeneration of muscle fibers; thinning of the outermost skin layer epidermis; and/or other associated findings. The chart below describes the common treatments for dermatomyositis and how they work. Drugs that suppress the immune system are the mainstay of therapy. Plaquenil for dermatomyositis Adverse cutaneous reactions to hydroxychloroquine are more., Taking Plaquenil for Rheumatoid Arthritis Chloroquine pi3 kinaseHow soon do effects of plaquenil takeHydroxychloroquine sulfate side effects rheumatoid arthritisPlaquenil side effects mouth sores Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Dermatomyositis - NORD National Organization for Rare Disorders. Plaquenil Use in Autoimmune Diseases. It should be noted that drugs in the antimalarial class such as hydroxychloroquine Plaquenil, chloroquine Aralen or quinacrine can themselves occasionally cause side effects in the muscles e.g. a vacuolar myopathy that can be confused for activity of dermatomyositis muscle disease activity. Hydroxychloroquine Plaquenil staves off my dermatomyositis symptoms far better than I thought. Hydroxychloroquine is cheap, relatively safe, and controls the heart and muscle inflammation associated with dermatomyositis. Dermatomyositis is a type of inflammatory myopathy characterized by inflammatory and degenerative changes of the muscles and skin. Associated symptoms and physical findings may vary widely from case to case as patients may present differently. Muscle abnormalities may begin with aches and weakness of the muscles of the trunk, upper arms, hips.