It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil blue skin Plaquenil bradycardia Chloroquine drug indication A single case report of use during pregnancy describes good disease control of systemic lupus erythematosus but mild Ebstein’s anomaly in the infant. It is unclear if belimumab is a teratogen based on this case report 43. Use of belimumab in pregnancy and lactation remains otherwise unstudied. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. The teratogenic risk related to the use of hydroxychloroquine is very low. Chloroquine may be used at prophylactic doses for malaria. In other situations, if continuation of the therapy is required for good control of the treated disease, the lowest possible dose should be used during pregnancy. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Hydroxychloroquine teratogenicity Hydroxychloroquine Side Effects, Dosage, Uses, and More, Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Ulcer plaquenilLariam vs plaquenilChloroquine method of action lysosomeHow does chloroquine work in the bodyPlaquenil autoimmune hepatitis Pharmacokinetics Following a single 200 mg oral dose of PLAQUENIL to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 daysthe same study, the plasma peak concentration was 50.3 ng/mL reached in 3.74 hours with a half-life of 2963 hours 123.5 days. Plaquenil Concordia Pharmaceuticals Inc. FDA Package Insert. Immunosuppressive drugs and fertility. Hydroxychloroquine Oral Uses, Side Effects, Interactions, Pictures.. Uses of Hydroxychloroquine It is used to treat or prevent malaria. It is used to treat lupus. It is used to treat rheumatoid arthritis. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. It may have both an anti- spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis.