The clinical trials on this list are studying Hydroxychloroquine. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. Plaquenil for lupus weight loss Chloroquin quinine Rheumatoid Arthritis Drug Linked to Cancer. Nov. 16, 2004 -- For people with rheumatoid arthritis, methotrexate is the treatment of choice in reducing pain and inflammation. But there's evidence the drug can activate a virus that can increase the risk of lymphoma and similar cancers in some patients. Lung cancer. The combination of HCQ with erlotinib can be used safely in daily doses of 150 mg erlotinib and 1000 mg HCQ, as determined by a phase-1 study in 27 patients with advanced non-small cell lung cancer NSCLC. Of the 19 patients who remained in the study, one had a partial response and four had stable disease as best response. Studies in genetically engineered mouse models demonstrate that autophagy inhibition suppresses lung tumor development and progression, especially in Kras mutated tumors. We report safety and efficacy of adding an autophagy inhibitor, hydroxychloroquine HCQ to front-line platinum-based chemotherapy in a phase Ib single arm study in patients with metastatic NSCLC. Talk to your doctor for help in deciding if one is right for you. You may want to think about taking part in a clinical trial. Hydroxychloroquine and lung cancer Hydroxychloroquine - Memorial Sloan Kettering Cancer Center, Repurposing Drugs in Oncology ReDO—chloroquine and. Chloroquine and lc3Magnesium and plaquenilWhat are plaquenil tablets used forPlaquenil and liver problemsWhat should a nurse monitor when taking hydroxychloroquine Non–small-cell lung cancer NSCLC is the most common cause of cancer mortality in the United States 1 and chemotherapy is only modestly effective. A Phase I Study of Erlotinib and Hydroxychloroquine in Advanced Non.. Modulation of autophagy with hydroxychloroquine in patients.. Chloroquine and hydroxychloroquine for cancer therapy. Hydroxychloroquine Plaquenil is also a disease-modifying anti-rheumatic drug DMARD used to treat both acute and chronic rheumatoid arthritis, systemic lupus erythematosus, and discoid lupus erythematosus. Hydroxychloroquine HCQ, one of the classic anti-malarial drugs, has been used to treat cancer in several preclinical studies and clinical trials. Previous study suggested that HCQ was active in suppressing cell migration and metastasis, both in vitro and in vivo 4. Hydroxychloroquine is a substance that decreases immune responses in the body. Palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Estrogen can cause the growth of breast cancer cells. Drugs, such as letrozole, may lessen the amount of estrogen made by the body.