Treatment of porphyria cutanea tarda with chloroquine

Discussion in 'Buy Chloroquine' started by yohann, 22-Feb-2020.

  1. LayeriBlall Well-Known Member

    Treatment of porphyria cutanea tarda with chloroquine


    Porphyria Cutanea Tarda (PCT) is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity). Affected skin is fragile and may peel or blister after minor trauma. PCT is essentially an acquired disease, but some individuals have a genetic (autosomal dominant) deficiency of UROD that contributes to development of PCT.

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    In 59 patients showing clear clinical and biochemical signs of porphyria cutanea tarda PCT, we tested 3 different modes of therapy 20 patients received combined treatment with repeated bleeding and chloroquine, 24 patients were exclusively treated with oral chloroquine in low doses, and 15 patients underwent repeated phlebotomy only. Treatment of porphyria cutanea tarda PCT with chloroquine risks serious side‐effects so we have combined it with phlebotomy. One to four venesections were performed before the administration of chloroquine in to PCT patients. Equally high excretion of urinary porphyrins was achieved but the side‐effects were reduced. Low-dose hydroxychloroquine or chloroquine. These drugs are recommended for patients in whom phlebotomy is contraindicated, difficult, or poorly tolerated. 15 Singal AK, Kormos-Hallberg C, Lee C, et al. Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea tarda.

    Most individuals with the inherited enzyme deficiency remain latent and never have symptoms. These individuals are referred to as having "familial PCT".

    Treatment of porphyria cutanea tarda with chloroquine

    Hydroxychloroquine DermNet NZ, Treatment of porphyria cutanea tarda with chloroquine and.

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  3. The skin lesions of pseudoporphyria closely resemble those seen in cutaneous forms of porphyria including porphyria cutanea tarda. Pseudoporphyria can occur at any age. Women are affected more often than men.

    • Porphyria Cutanea Tarda - NORD National Organization for..
    • Porphyria cutanea tarda - Approach BMJ Best Practice.
    • Treatment of Porphyria cutanea tarda - News Medical.

    Chloroquine treatment can induce porphyria attacks within the first couple of months of treatment due to the mass mobilization of porphyrins from the liver into the blood stream. Complete remission can be seen within 6–12 months as each dose of antimalarial can only remove a finite amount of porphyrins and there are generally decades of accumulation to be cleared. PCT patients with hemochromatosis are reportedly resistant to chloroquine, 41 and are more appropriately treated by phlebotomy, considering other adverse effects of iron overload. Specific contraindications for phlebotomy included hemoglobin 10 g/dL or hematocrit of 33, and poor venous access. Dec 20, 2019 Kordac V, Semradova M. Treatment of porphyria cutanea tarda with chloroquine. Br J Dermatol. 1974 Jan. 90195-100. Battle AM, Stella AM, De Kaminsky AR, Kaminsky C, Mariano HG. Two cases of infantile porphyria cutanea tarda successful treatment with oral S-adenosyl-L-methionine and low-dose oral chloroquine.

     
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    Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Hydroxychloroquine toxicity - EyeWiki Hydroxychloroquine Professional Patient Advice - Maculopathy - an overview ScienceDirect Topics
     
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