In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Can you use plaquenil if allergic to quinine Hydroxychlor plaquenil Retinal toxicity related to hydroxychloroquine in patients with systemic lupus erythematosus and rheumatoid arthritis. Telek HH, Yesilirmak N, Sungur G, Ozdemir Y, Yesil NK, Ornek F. Doc Ophthalmol. 2017 Dec; 1353187-194. The incidence of retinal toxicity is associated with the cumulative dose of the drug, increasing significantly beyond 1,000 g of HCQ. This cumulative dose is created when the common dose of 400 mg/day is used for 6.8 years. Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. Ocular side effects of hydroxychloroquine can include impact on the cornea, ciliary body, lens and retina. 1 Corneal deposits, fortunately, rarely affect vison. 2 However, the concern of retinal toxicity and the need for monitoring must be reviewed with patients prior to and during its use. 2,3 As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Retinal toxicity of hydroxychloroquine Retinal Physician - New Screening Guidelines for Hydroxychloroquine., Retinal Physician - Hydroxychloroquine Maculopathy An. Can u smoke on hydroxychloroquine Hydroxychloroquine Retinal Toxicity. Proano C1, Kimball GP2. Author information 1Watts Eye Associates, Newburyport, MA [email protected] 2Haverhill, MA. PMID 31018072 Indexed for MEDLINE Publication Types Case Reports; MeSH terms. Antirheumatic Agents/adverse effects* Hydroxychloroquine Retinal Toxicity.. Ocular Disease Monitoring Critical to Avoid Retinal Toxicity from.. Retinal Toxicity in Patients Treated With.. Hydroxychloroquine is associated with long-recognized retinal toxicity. 2, 3, 4 The retinopathy is hallmarked by parafoveal changes within the retina. Early toxicity may be asymptomatic. Hydroxychloroquine toxicity Disease Entity. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity. Diagnosis. For retinopathy, patients should be asked about poor central vision. Management. At the first signs of retinal toxicity, hydroxychloroquine should be stopped. The risk of developing retinal toxicity has been found to be dependent on the daily HCQ dose and the duration of use. The risk of retinal toxicity is 1% for those who use HCQ for up to 5 years and 2% for those who use HCQ for 5–10 years, but it rises to almost 20% after 20 years of HCQ use.